Department of Imaging Physics, Delft University of Technology

Education

Abstract

This page shows the possibilities for BSc and MSc student projects in KaLKMaNLaB. When you have a project proposal of your own or you want to know more details, please contact KaLKMaNLaB.

Student projects



BSc projects

Diverse BSc projects are available and their scope varies regularly. Please contact us if you are interested in a BSc end project on optical tomography.

Multi-wavelength optical diffraction tomography (MSc)

The future of imaging is 3D. In this project you will develop a new 3D imaging method based on optical diffraction tomography (ODT). ODT is an imaging modality capable of acquiring 3D images of the refractive index of an object. ODT is based on measuring projections of the phase of light travelling through an object. An example of ODT is show below where we have imaged a zebrafish in 3D. Currently, ODT is limited to optically cleared tissue as it is incompatible with the presence of optical attenuation in the form of absorption or scattering. To widen the applicability of ODT it would be very advantageous if the technique could be applied to mildly or non-cleared tissues as well. The goal of this MSc. project is to explore the use of multi-wavelength ODT to accomplish 3D imaging of attenuating tissues. You will do this utilizing the knowledge and technology of optical coherence tomography to perform time gating of the acquired optical field.

Pathology in a new light with label-free deep-tissue microscopy (MSc)

The study of cells, tissues, and organisms is of great importance for biologists discovering the mechanisms of life and death. An important part of these studies is performed with microscopic imaging techniques. Currently, we are developing a new imaging technique called transmission confocal coherence microscopy (TCCM). TCCM is based on low-coherence interferometry to filter unscattered light from the scattered light. In this way, it is potentially possible to image 4 millimeters deep into tissue with the advantage of phase contrast imaging. We apply this technique to clinical pathology of tissue. The goal of this MSc. project is first to improve the resolution of this technique to the micrometer level through the design and implementation of an improved set up. Second, you apply the depth sectioning capability to make high resolution 2D images of tissue. Third, you apply the technique to clinically relevant samples such as tissue biopsies.